In my case the major event is the Reformation.
Through working in the descendents of Lucas Cranach the Elder, I have discovered many major players in events of the times, including an indirect link to Martin Luther for whom there are no direct descendents.
The results of what I have learned so far are detailed on my website on the Reformations Connections page.
It is amazing what you can learn from fellow researchers and random searches. The German and English Wikipedia were extremely helpful in filling in lineages and also providing a lot of information about many of these individuals. Doctors, lawyers, preachers, printers and artists all had their roles to play.